(IMAGE)
Caption
Prophylactic treatment of NF-κB decoy ODN-loaded PLGA nanospheres local administration prevents alveolar bone loss and promotes wound healing after tooth extraction. PLGA-NfD demonstrates inhibitory effect on osteoclast differentiation and inflammatory cells (Upper), including the reduction of alveolar bone resorption, thereby allowing the continuing dynamic healing potential to accelerate new bone formation in the extraction socket, as assessed by bone-labeling technique with calcein (green), demeclocycline hydrochloride (yellow), and alizarin complexone (red) (Lower). Abbreviations: NfD, naked NF-κB decoy; NF-κB, nuclear factor-kappa B; ODN, oligodeoxynucleotide; PBS, phosphate-buffered saline; PLGA, poly(lactic-co-glycolic acid); PLGA-NfD, NF-κB decoy ODN-loaded PLGA nanosphere; PLGA-ScD, scrambled decoy ODN-loaded PLGA nanosphere; ScD, naked scrambled decoy.
Credit
Department of Orthodontic Science, TMDU
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