Figure 1. Analyzing the effect of amide-to-ester substitution on the permeability of cyclic peptides. (IMAGE)

Tokyo Institute of Technology

Figure 1. Analyzing the effect of amide-to-ester substitution on the permeability of cyclic peptides.

Caption

(Left) (a) Chemical structures of model dipeptides. (b) List of dipeptide molecules synthesized. (c) Parallel artificial membrane permeability assay (PAMPA) of the dipeptides. (Right) (d) Chemical structures of model cyclic hexapeptides. (e) List of hexapeptide molecules synthesized. (f)&(g) PAMPA and Caco-2 assay of the synthesized cyclic hexapeptides.

Credit

Nature Communications

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