Mechanism of neurological side effects by antisense oligonucleotides (IMAGE)

Tokyo Medical and Dental University

Mechanism of neurological side effects by antisense oligonucleotides

Caption

Antisense oligonucleotides for treatments of neurological diseases, directly injected into　cerebrospinal fluid in spaces around the brain, may cause side effects, abnormalities of consciousness or motor function. These side effects can be predicted by calcium decrease in neuronal cells.

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Department of Neurology and Neurological Science, TMDU

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