Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the AD model mouse brain (IMAGE)

Tokyo Medical and Dental University

Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the AD model mouse brain

Caption

The newly developed antibody 6H4 fragments (Fabs) specific to Aβ oligomers, encapsulated in the polymeric nanomicelles (PMs), were peripherally administrated to AD model mouse for 10 weeks. In mice that were administered anti-AβO 6H4 Fabs in the PMs, various toxic Aβ species (Aβ oligomers, Aβ42s, N3pE Aβs, Aβs with toxic conformer) and the presence of Aβ plaques with dense cores in the brain were significantly reduced. Additionally, suppression of the progression of pathological processes of AD was supported by the prevention of cognitive-behavioral decline in the spatial memory tests.

Credit

Department of Neurology and Neurological Science, TMDU

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.