Vitellogenin accumulation leads to reproductive senescence by impairing lysosomal function (IMAGE)
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Yolk proteins are the most abundant proteins in eggs, which are composed of lipids and lipid-binding proteins called vitellogenins (vit) . In both vertebrates and invertebrates, the yolk proteins are synthesized by a tissue outside the gonad, and deposited into oocytes by a vitellogenin receptor RME-2 to provide essential nutrients to support the development of the embryo in a process called vitellogenesis. With the increase of nematode age, excess vitellogenin is accumulated in the intestine and transported into the germline via RME-2, impairing lysosomal activity in these tissues，which leads to the deterioration of oocyte quality. Downregulation of vitellogenin vit gene expression by knockout or silencing promoted the expression of lysosomal acid lipase gene lipl-4 . lipl-4 may promote the activity of lysosomes by increasing the content of PUFAs, inhibit the accumulation of vitellogenin in the germline, improve the quality of oocytes, and delay the reproductive aging of C. elegans.
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