Proposed mechanism for the PCB2DG-mediated suppression of glutamine influx and IFN-γ production via the direct interaction with ASCT2 in CD4+ T cells (IMAGE)

Shinshu University

Proposed mechanism for the PCB2DG-mediated suppression of glutamine influx and IFN-γ production via the direct interaction with ASCT2 in CD4+ T cells

Caption

The inhibition of IFN-γ production in CD4+ T cells caused by the dietary polyphenol PCB2DG was mediated by the activation of the AAR pathway through inhibition of glutamine influx via the direct interaction of PCB2DG with ASCT2.

Credit

KATSUNORI ENDO AND SACHI TANAKA, SHINSHU UNIVERSITY

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