Schematic of the new analytical platform. (IMAGE)

Tokyo Metropolitan University

Schematic of the new analytical platform.

Caption

A mRNA molecule (p-RNA) is mixed with a standard (s-RNA) labelled with stable isotopes (SI) before being digested then characterized using a combination of liquid chromatography and mass spectrometry (LC-MS). The output is analyzed using Ariadne software to yield information on the sequence, the state of the “cap,” and the length of the tail. This yields vital information on the quality of the mRNA medicine.

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Tokyo Metropolitan University

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