Duke-NUS Kidney Regeneration (VIDEO)
Caption
Researchers in Singapore and Germany have found that renal tubular cells, which line the tiny tubes inside kidneys, release interleukin-11 (IL-11), a scar-regulating protein, in response to kidney damage. This leads to increased expression of a gene that arrests cellular growth and promotes kidney dysfunction. In a preclinical model of human diabetic kidney disease, the scientists showed that turning off this process by administering an antibody that binds to IL-11 led to proliferation of the kidney tubule cells and reversal of fibrosis and inflammation, enabling damaged kidney cells to regenerate and restoring impaired kidney function.
Credit
Duke-NUS Medical School
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