OASCLR exerted great therapeutic effects against primary pneumonia and second pneumonia (IMAGE)
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In the upper can be seen the formation process of OASCLR and OASCLR for bacterial pneumonia treatment. The remaining part is the schematic illustration of OASCLR against primary and second pneumonia. First, OASCLR killed various pathogens. On the other hand, OASCLR altered the composition of the lung microbiome. In addition, OASCLR targeted M1 macrophages by HA-CD44 interactions and modulated the overactivated immune response of macrophages. And Specifically, OASCLR inhibited inflammatory response at primary pneumonia. More importantly, OASCLR enhanced the phagocytosis ability of macrophages at second pneumonia by down-regulating the expression of SP-D.
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