A novel endothelial lineage that majorly contributes to the vascular niche for HSPCs (IMAGE)

National Cerebral and Cardiovascular Center

A novel endothelial lineage that majorly contributes to the vascular niche for HSPCs

Caption

Figure 1. (A) Live imaging of the tail of a zebrafish embryo, in which islet1+-derived ECs (green) and the other ECs (magenta) were labeled at different colors. islet1+-derived ECs (green) are mainly located in the caudal hematopoietic tissue (CHT), a transient vascular niche for HSPCs. (B) The number of HSPCs in the CHT is markedly decreased in embryos depleted of islet1-derived ECs. (C) We have identified that islet1+ endothelial progenitors originate from endoderm and finally differentiate into posterior venous ECs in a process dependent on Bmp-Smad signaling, requiring Npas4l-Etsrp function. Eventually, these ECs mainly contribute to the vascular hematopoietic niche in the CHT.

Credit

Developmental Cell/Nature communications/ National Cerebral and Cardiovascular Center

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