Initial open structure (IMAGE) The University of Hong Kong Caption An initial open structure (IOS) is formed upon binding of human MCM double hexamer (hMCM-DH) to origin DNA. Image modified from original illustration of Li et al, 2023 Cell 186, 1-14. Credit The University of Hong Kong Usage Restrictions N/A License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.