Fig. 1 (IMAGE)
Caption
TGCV is an emerging cardiovascular disorder characterized by diffuse narrowing coronary atherosclerosis with triglyceride (TG) deposition caused by defective intracellular lipolysis. TGCV is an often-undiagnosed condition in patients who are resistant to standard therapies. Panels A and B concern two patients in their 60s with refractory angina pectoris and diabetes mellitus. After being diagnosed with TGCV, they started dietary intake of tricaprin. Their symptoms improved within a couple of months. Follow-up coronary computed tomography angiography showed marked regression of atherosclerotic lesions with luminal dilatation (left coronary artery shown as red line in upper panel A; right and left coronary arteries in upper panel B). The low-attenuation area observed from the adventitial side (yellow and orange area, in the middle, panel A) and its volume (yellow bars in the middle, panel B) were reduced, indicating ameliorated lipid involvement. These observations were associated with increased myocardial lipolysis on iodine-123-β-methyl-p-iodophenylpentadecanoic acid scintigraphy (lower panels).
Credit
2022, Ken-ichi Hirano, Remarkable regression of diffuse coronary atherosclerosis in patients with triglyceride deposit cardiomyovasculopathy., European Heart Journal
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License
CC BY-NC