Mechanism of body temperature regulation (IMAGE) Nagoya University Caption In hot environments, EP3 neurons in the preoptic area continually send inhibitory signals with GABA to suppress sympathetic outflows to defend body temperature from ambient heat. In cold environments or during infections, EP3 neurons are inhibited and therefore, sympathetic pathways are activated to increase heat production and inhibit heat loss to prevent hypothermia or to develop fever. The activity level of EP3 neurons is a critical determinant of body temperature. Credit © 2022 Yoshiko Nakamura Usage Restrictions This image may be used with appropriate credit. License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.