Role of MTM1-mediated endosomal PI(3)P signaling in mitochondrial metabolic rewiring via reshaping the ER in response to starvation (IMAGE)

Leibniz-Forschungsinstitut für Molekulare Pharmakologie

Role of MTM1-mediated endosomal PI(3)P signaling in mitochondrial metabolic rewiring via reshaping the ER in response to starvation

Caption

In fed cells, early endosomes form contacts with ER tubules. Tubular ER membranes facilitate mitochondrial fission and serve as source for lipid droplet formation. Nutrient starvation-induced hydrolysis of endosomal PI(3)P by MTM1 reduces membrane contacts between the tubular ER and early endosomes. The resulting loss of peripheral ER tubules induces mitochondrial network formation and the delivery of fatty acids to mitochondria to sustain cellular energy supply.

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Jang et al; Science

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