TME reprograming with Tranilast-loaded polymeric micelles (IMAGE)

Innovation Center of NanoMedicine

TME reprograming with Tranilast-loaded polymeric micelles

Caption

Polymeric, tranilast-loaded micelles effectively reprogram the tumor microenvironment in mouse breast tumors to restore perfusion and thus, improve drug delivery and immune cell infiltration into the tumor. As a result, the polymeric micelles potentiate anticancer therapy with epirubicin-micelles and immunotherapy leading to cure and immunological memory. (Image adjusted from Panagi M et al., 2022, doi: 10.7150/thno.72800)

Credit

Horacio Cabral

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University of Tokyo

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