A working model of IFNγ-STAT1 signaling promoting axon regeneration in CNS and PNS. (IMAGE)

Hong Kong University of Science and Technology

A working model of IFNγ-STAT1 signaling promoting axon regeneration in CNS and PNS.

Caption

In CNS, such as retinal ganglion cells, IFNγ activates STAT1 in Ptpn2 cKO RGCs. STAT1 then upregulates neuronal cGAS expression. cGAS produces cGAMP and activate STING in neurons. In PNS, such as dorsal root ganglion, axotomy induces IFNγ expression in axons by local translation. And IFNγ activates STAT1-cGAS signaling and cGAMP production in surrounding Schwann cells and blood cells, to promote peripheral axon regeneration.

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The Hong Kong University of Science and Technology

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