Organoid butterflies on NASH spider web (IMAGE)
Caption
Non-alcoholic steatohepatitis (NASH) is a common disease that affect nearly billion people globally and so early identification of susceptible individuals is critical for precision hepatology. In this issue, Takebe et al. use human liver organoids and perform en masse population-based phenotypic analysis under insulin insensitive conditions to investigate key NASH-genetic factors. In the image, multiple flying butterflies with liver-like wings suggest liver organoids at “population” scale. Some butterflies are caught by the “NASH” spider web, which illustrates steatohepatitis-like phenotype. This is a metaphor that genetic association can be better captured in a certain metabolic state, enabling efficient evaluation of genetic markers for common disorders like NASH.
Credit
Institute of Research, TMDU
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