Residual colorectal cancer tumor cell extravasating from a liver portal vein. (IMAGE)
Caption
Colorectal Cancer organoids, edited to express a tdTomato reporter in cells with high Epithelial membrane protein 1 (Emp1) expression, were implanted in the caecum of mice to generate primary tumors. After several weeks, we sectioned whole livers and stained for tdTomato (in red) and E-Cadherin (grey) to look for metastasis initiating cells. In the picture it can be observed how CRC disseminating tumor cells express high levels of Emp1, a marker gene of the High-relapse cell (HRC) population we describe.
Credit
IRB Barcelona
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