Pacemaker Channel Discovery Could Lead to Better Heart Drugs (IMAGE)
Caption
Lipids bind to pacemaker ion channels to unlock their gates. Top: Side view of the structure of SthK channels (blue) with bound lipids (orange). Bottom: Bottom view of the channel pore opening as it transitions, from left to right, from closed and locked, to closed and unlocked, to open. Channel protein is in blue and grey cartoon, lipids are represented by orange keys, channel locked closed is indicated by a dark grey lock, channel unlocked is indicated by a light grey lock, and channel open is indicated by the enlargement of the pore size (rightmost panel). The lipid binding and channel opening transitions are indicated above the arrows.
Credit
Weill Cornell Medicine
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