Freestanding vascular constructs recapitulating anatomically relevant geometries and multilayered structure of a blood vessel. (IMAGE)

Singapore University of Technology and Design

Freestanding vascular constructs recapitulating anatomically relevant geometries and multilayered structure of a blood vessel.

Caption

Photographs of planar vascular models: A) straight vascular construct, B) bifurcating vascular construct, C) vascular constructs with multiple branches, and D) aortic arch. Illustrations and photographs of 3D vascular models: E,F) a nonplanar biomimetic branching network (one inlet to seven branches), G,H) a nonplanar vascular tree (one inlet to nine branches). Image of a bifurcating vascular construct consisting of four layers (as depicted by the encapsulated fluorescent beads of different colors) shown in I) top view and J) cross-sectional view. Cross-sectional image of multilayered vascular construct consisting of K) Alg-GM in the outer layer and fibrin hydrogel in the inner layer, and L) Alg-PEGDA in the outer layer and Alg-GM in the inner layer. Scale bars: (I) 1 mm, (C,D,F,H) 5 mm, (J–L) 500 µm. Circular reference (diameter): A, B) 18.50 mm.

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SUTD

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