AAV-based screening for CaMKIIβ phosphomimetic mutants (IMAGE)

Japan Science and Technology Agency

AAV-based screening for CaMKIIβ phosphomimetic mutants

Caption

Wild-type mice were administered with AAVs (adeno-associated viruses) to express the CaMKII mutant (upper right) and their sleep phenotypes were analyzed (upper left). Comprehensive analysis of mice administrated with 69 AAVs corresponding to CaMKIIβ phosphomimetic mutants revealed that T287D (T287D), a phosphomimetic mutant of T287, remarkably extended sleep duration (below).

Credit

2022 Tone et al.

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CC BY

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