TGF-β orchestrates proliferation and migration of cancer cells via KRTAP2-3 (IMAGE)

Tokyo Medical and Dental University

TGF-β orchestrates proliferation and migration of cancer cells via KRTAP2-3

Caption

Takahashi et al. show that TGF-β generates a population of cancer cells under cell cycle arrest in G1 phase with high motility by inducing unique Slug/HMGA2-independent epithelial-mesenchymal transition (EMT). This leads to tumor progression and poor prognosis for patients with head and neck cancer.

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Department of Biochemistry, TMDU

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