Ancient viral remnants in the human genome are active in normal tissues (IMAGE)
Caption
HML-2 ORF Transcripts in the Human Body: This map of the human body (adapted from the GTEx consortium website with permission) displays the possible expressed Human endogenous proviral HML-2 ORFs in each tissue sampled. Blue shapes represent Gag, green represent Pro, pink represent Env and orange/purple represent Rec and Np9 respectively. A square indicates expression due to read through transcription from an adjacent or surrounding gene or otherwise undetermined. A triangle demonstrates LTR driven transcription of viral ORF shown. This map displays the wide range of HML-2 viral ORFs that could be transcribed throughout the body in non-diseased tissue.
Credit
Burn A et al., 2022, PLOS Biology, CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/)
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Credit must be given to the creator.
License
CC BY