Scheme of the incorporation of evybactin and resistance mechanism (IMAGE)

Shinshu University

Scheme of the incorporation of evybactin and resistance mechanism

Caption

The mechanism of selectivity of evybactin. Evybactin (EVY) is transported into the bacterial cell by BacA (M. tuberculosis) and SbmA (E. coli) transporters. However, in E. coli, evybactin is removed by drug efflux pump AcrAB-TolC. As a result, evybactin selectively kills M. tuberculosis.

Credit

ADAPTED FROM IMAI, Y., HAUK, G., QUIGLEY, J. ET AL. EVYBACTIN IS A DNA GYRASE INHIBITOR THAT SELECTIVELY KILLS MYCOBACTERIUM TUBERCULOSIS. NAT CHEM BIOL (2022). HTTPS://DOI.ORG/10.1038/S41589-022-01102-7, COPYRIGHT © 2022, THE AUTHOR(S), UNDER EXCLUSIVE LICENCE TO SPRINGER NATURE AMERICA, INC.

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