PITPNC1 regulates mitochondrial lipid homeostasis and plays an important role in maintaining body temperature in mice under acute cold exposure (IMAGE)
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On the left, single-housed 8-week-old male littermates of wildtype mice and Pitpnc1-/- mice were fasted for 4 h and then maintained at 22oC or switched to a 4oC cold room. Schematic diagram shows the process of acute 4oC cold exposure performed on wildtype mice and Pitpnc1-/- mice. The results show that Pitpnc1 gene is necessary for the mice to maintain their body temperature under acute cold exposure. On the right, the schematic diagram of the model shows the physiological significance of PITPNC1 in regulating mitochondrial lipid homeostasis for heat production of brown adipocytes under acute cold exposure.
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