HUSH and NEXT complexes (IMAGE)
Caption
The HUSH and NEXT complexes function to control expression of TE transcripts at either the transcriptional or post-transcriptional level, respectively. HUSH is recruited to TE loci decorated with H3K9me3 histone marks and is required for transcriptional (txn) suppression. NEXT is recruited to HUSH-bound loci through a physical connection that requires ZCCHC8 and MPP8 and functions to decay pA- RNAs produced at TE loci
Credit
William Garland, Aarhus University
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Image may be used only to illustrate the research described in the accompanying release.
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Original content