Mouse neural tube (IMAGE)

The Company of Biologists

Mouse neural tube

Caption

A developing mouse neural tube. Hedgehog signalling is required to produce different types of neuronal progenitor cells, indicated by the different colours. THC inhibits Hedgehog signalling in genetically susceptible mice, leading to developmental defects, including in the neural tube.

Credit

Lo, H.-F., Hong, M., Szutorisz, H., Hurd, Y.L., Krauss, R.S. (2021). Δ9-Tetrahydrocannabinol inhibits Hedgehog-dependent patterning during development. Development, 148, dev199585. doi:10.1242/dev.199585

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