Overcoming resistance to chemotherapy by miR-634 (IMAGE)

Tokyo Medical and Dental University

Overcoming resistance to chemotherapy by miR-634

Caption

In OSCC, the expression of miR-634 target genes is upregulated and contributes to the resistance to cisplatin (CDDP). miR-634 introduction into OSCC cells overcomes CDDP resistance by simultaneously targeting multiple genes associated with cytoprotective processes. In this study, we newly identified cIAP1, which plays a central role in the anti-apoptotic process, as a target of miR-634.

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Department of Molecular Cytogenetics, TMDU

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