Path of remdesivir (IMAGE)

National Institutes of Natural Sciences

Path of remdesivir

Caption

Remdesivir (shown in the sphere model) is transferred to two magnesium ions (yellow-green spheres) at the binding site of the RNA polymerase (shown in the ribbon model) while being passed from one lysine residue (shown in the stick model) to another. We can see that the lysine residues transfer remdesivir as if it were a bucket brigade.

Credit

ExCELLS/IMS, S. Tanimoto, S. G. Itoh, and H. Okumura

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