Dr Ksenija Nesic and Professor Clare Scott (IMAGE)
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Researchers have made a discovery that could help more women with ovarian cancer gain access to game-changing cancer treatments called PARP inhibitors. The research team found tumours from some ovarian cancer patients had changes that silenced a gene involved in DNA repair and showed that this made tumours sensitive to PARP inhibitors. The discovery identifies a new group of patients who are likely to benefit from the therapy and who should be included in trials of PARP inhibitors. It also indicates these women should be closely monitored for changes that affect gene silencing, which could render their cancers resistant to therapy. The research was led by Dr Ksenija Nesic (left) and Professor Clare Scott (right) from the Walter and Eliza Hall Institute (WEHI) in Melbourne, Australia, with collaborators in Australia and the US.
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WEHI
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