Figure 1 (IMAGE)

Arizona State University

Figure 1

Caption

The graphic shows the basic experimental setup for Surface Plasmon Resonance Microscopy (SPRM). When a particle of interest binds with a receptor, tethered to a thin gold film, the event disturbs a surface plasmon wave, which is registered as a change in light intensity. SLED (for super-luminescent emitting diode) is the light source, which illuminates the sample and induces a surface plasmon wave that ripples across the gold surface. A high speed camera captures these rapid changes, imaging the binding dynamics.

Credit

Adapted with permission from Three-Dimensional Tracking of Tethered Particles for Probing Nanometer-Scale Single-Molecule Dynamics Using a Plasmonic Microscope Copyright 2021 American Chemical Society.

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