Cross section retinal organoids (IMAGE)
Caption
Cross-section through part of a retinal organoid: On day 143 of their differentiation, the inner nuclear layer (bottom) contains the cell bodies of functionally distinct cells: those of the amacrine and horizontal cells (white) and Müller glial cells (red). The outer nuclear layer (top) contains the cell bodies of the photoreceptors (light-sensitive cells; green). The sketch on the right shows the cell types and structure of the vertebrate retina in the same orientation as in the organoid: Here, light enters from below and traverses the entire retina until it hits the photoreceptors (top cell layer in gray). The inner nuclear layer contains amacrine and horizontal cells (white) and bipolar cells (green). Müller glial cells (red) span the entire retina. The axons of the retinal ganglion cells (gray) form the optic nerve and transmit the light signal to the brain.
Credit
MPI for Molecular Biomedicine/ Yotam Menuchin-Lasowski
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