Neutrophils (IMAGE)
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Scripps Research scientists found a protein in immune cells (called neutrophils) that could be a target against harmful inflammation. An imaging technique called Stochastic Optical Reconstruction super-resolution Microscopy (STORM, right image) shows that in resting neutrophils, the WASH protein complex (green) forms a molecular clustered complex with microfilaments called F-actin (red) and with granule cargo (blue) near the plasma membrane (left image). In the absence of WASH, the actin nucleator Arp2/3 (right, pink) has reduced activity, facilitating toxic granule (right, green) secretion, leading to systemic inflammation.
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Scripps Research
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