Targeting PI3K/mTOR pathway decreases Cyclin D1/CDK4 protein translation and restores CDK4/6 inhibitors sensitivity in breast cancer. (IMAGE)

Science China Press

Targeting PI3K/mTOR pathway decreases Cyclin D1/CDK4 protein translation and restores CDK4/6 inhibitors sensitivity in breast cancer.

Caption

The CDK4/6 inhibitors-resistant breast cancer cells expressed more Cyclin D1 and CDK4 proteins than the parental cells (Upper left). PI3K pathway was hyper-activated in the resistant cells (Upper right). Targeting PI3K/mTOR pathway with BYL719 (BYL, PI3Kα inhibitor） or everolimus （EVMS，mTOR inhibitor）reduced CDK4 and Cyclin D1 expression (Lower left) and restored CDK4/6 inhibitor sensitivity in the resistant cells (Lower right).

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