Characteristics of Clonal Hematopoiesis (CH) Mutations (IMAGE)
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: a) We identified somatic mutations in known clonal hematopoiesis of indeterminate potential (CHIP) driver genes using peripheral blood mononuclear cells isolated from 14 astronauts who flew short space Shuttle missions lasting a median of 12 days between 1998–2001. Created with BioRender.com. b) Number of somatic nonsynonymous single nucleotide variants (SNVs) in CHIP-driver genes harbored per subject. c) Rates of different substitution types observed in clonal SNVs. Only one guanine to thymine transition was observed. d) Density of mutations by VAF for each mutation type.
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Communications Biology / Mount Sinai Health System
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