MSH1 repair of organelle DNA (IMAGE)
Caption
MSH1 repairs organelle DNA. The MSH1 protein slides along a DNA strand until it detects mutations. Then MSH1 cuts both strands of DNA. The DNA repair machinery in the cell uses homologous DNA (DNA of the same sequence) as a template to fix the mutation. B) MSH1 increases sorting of organelle DNA. A population of green (normal) and blue (mutant) organelle DNA molecules is shown. When functional MSH1 is present, it homogenizes copies of DNA, and the resulting populations contain either normal or mutant DNA. When MSH1 is absent, the DNA types remain mixed.
Credit
Amanda Broz/Colorado State University
Usage Restrictions
None
License
Original content