Discovery of a Defective SIGIRR-dependent Anti-inflammatory Pathway in Cystic Fibrosis (IMAGE)
Caption
A new study discovers that a spliced isoform of the SIGIRR protein suppresses an anti-inflammatory pathway in lung epithelial cells of patients with CF. It clarifies the mechanism through which ∆8-SIGIRR suppresses the anti-inflammatory effects of IL-37 in CF lung epithelial cells, resulting in activation of TLRs.
Credit
Tsuyoshi Shuto from Kumamoto University
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