Impact of Down syndrome (IMAGE) BGI Genomics Caption Down syndrome, often presents moderate to severe intellectual disability and physical developmental abnormalities and has an incidence of about 1 in 800 to 1 in 1000, which increases significantly with maternal age Credit BGI Genomics Usage Restrictions Journalists are free to use in their content License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.