The diagram shows how increased sST2 levels in AD impair microglial clearance of amyloid pathology (IMAGE)

Hong Kong University of Science and Technology

The diagram shows how increased sST2 levels in AD impair microglial clearance of amyloid pathology

Caption

The diagram shows how increased sST2 levels in AD impair microglial clearance of amyloid pathology: increased levels of sST2 protein (1) in the blood enter the brain; this decoy receptor blocks the normal signaling stimulated by IL-33 in microglia (2). The inhibition of IL-33 signaling leads to reduced clearance of Aβ by microglia (3), resulting in an increase in Aβ plaque load (4).

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HKUST

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