Pancreatic development in wild type mice vs. mice without PTF1A (IMAGE)

Center for Genomic Regulation

Pancreatic development in wild type mice vs. mice without PTF1A

Caption

Mice with a deletion in the pancreas agenesis enhancer do not express PTF1A (green) in embryonic multipotent pancreatic progenitors, leading to underdeveloped pancreas and insulin-deficient diabetes. Immunofluorescence of embryonic pancreatic buds from control (left) and enhancer-deleted (right) mice stained for PTF1A (green), PDX1 (red), glucagon (blue).

Credit

Miguel Angel Maestro/Developmental Cell.

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License

CC BY-ND

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