The mechanism of MHC I assembly, epitope editing and quality control within the peptide loading complex (PLC). (IMAGE)

Goethe University Frankfurt

The mechanism of MHC I assembly, epitope editing and quality control within the peptide loading complex (PLC).

Caption

The fully assembled PLC machinery of antigen processing is formed by the antigen transport complex TAP1/2, the chaperones calreticulin, ERp57, and tapasin, and the heterodimeric MHC I (heavy and light chain in teal and green, respectively).

Credit

Christoph Thomas & Robert Tampé, Goethe University Frankfurt, Germany

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