Theoretical proposal for an Alzheimer’s disease (AD) model (ATPNO) and the biomarkers for in vivo measurements of the model dimensions (IMAGE)

IOS Press

Theoretical proposal for an Alzheimer’s disease (AD) model (ATPNO) and the biomarkers for in vivo measurements of the model dimensions

Caption

The model dimensions include amyloidosis (A), tauopathy (T), pathophysiology (P), and neurodegeneration (N). The disease processes within those dimensions produce a clinical output (O) involving vigilance, sleep-wake cycle, cognitive functions, and abilities in the activities of daily living. Key: CSF, cerebrospinal fluid; PET, positron emission tomography; EEG, electroencephalography; ERO, event-related EEG oscillations; ERP event-related potentials; MRI, magnetic resonance imaging; FDG-PET, fluorodeoxyglucose-positron emission tomography.

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Journal of Alzheimer’s Disease

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