Possible mechanisms of NF-κB pathway activation in severe COVID-19 (IMAGE)

Fujita Health University

Possible mechanisms of NF-κB pathway activation in severe COVID-19

Caption

The activation of NF-κB pathway is a complex process where the interaction of different molecular players leads the induction of proinflammatory cytokines. (A) TRIM13 ubiquitinates NSP6, which promotes the recruitment of the IKK/NEMO complex and the activation of NF-κB. Next, NEMO is ubiquitinated, which further promotes the recruitment of the IKK/NEMO complex. (B) RNF121 ubiquitinates ORF7a before recruiting TAK1 and the IKK/NEMO complex to the ubiquitin chain. Ubiquitination of NEMO itself is not needed for NF-κB activation in the case of ORF7a.

Credit

Prof. Takayuki Murata, Fujita Health University School of Medicine

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