Structural view of binding between the Stx2a A-subunit and compound #6. (IMAGE)

Doshisha University

Structural view of binding between the Stx2a A-subunit and compound #6.

Caption

Researchers from Japan used a peptide-based pharmacophore to identify a potent molecule that binds to and inhibits the bacterial Shiga toxin, Stx2a. Results suggest that the novel compound #6 may be an effective therapeutic agent against enterohemorrhagic E. coli (EHEC) infections.

Credit

Image credit: Prof. Kiyotaka Nishikawa from Doshisha University, Japan Image link: https://www.nature.com/articles/s41598-022-15316-1

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