PAN protein domain (IMAGE) DOE/Oak Ridge National Laboratory Caption ORNL scientists identified four amino acids key to signaling pathways in the PAN protein domain. Mutating any of those four resulted in disruption of the signal that tells cancer cells to multiply and spread in humans. Credit Andy Sproles/ORNL, U.S. Dept. of Energy Usage Restrictions None License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.