Cas9 Encounters Off-target DNA (IMAGE)

University of Texas at Austin

Cas9 Encounters Off-target DNA

Caption

The researchers were surprised to discover that when Cas9 encounters a mismatch in a certain part of the DNA (red and green), instead of giving up and moving on, it has a finger-like structure (cyan) that swoops in and holds on to the DNA, making it act as if it were the correct sequence.

Credit

Jack Bravo/University of Texas at Austin

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