Scientists have demonstrated the pivotal role of an enzyme, glucose-6-phosphate dehydrogenase (G6PD), in facilitating ovarian cancer (OC) growth and metastasis in the omentum, a curtain of fatty tissue found in the abdominal cavity. (IMAGE)

Terasaki Institute for Biomedical Innovation

Scientists have demonstrated the pivotal role of an enzyme, glucose-6-phosphate dehydrogenase (G6PD), in facilitating ovarian cancer (OC) growth and metastasis in the omentum, a curtain of fatty tissue found in the abdominal cavity.

Caption

Metastatic ovarian cancer cells migrate and proliferate aggressively in the omental environment and metabolizes its fatty acids as fuel. In the process, a buildup of harmful oxidative compounds occurs. This can be offset by the activation of the G6PD-controlled pentose phosphate pathway.

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Cell Reports

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