Fragile telomeres (IMAGE)

University of Pittsburgh

Fragile telomeres

Caption

X-shaped chromosomes are stained purple, and telomeres appear as green spots at chromosome tips. When researchers used a novel tool to induce oxidative damage specifically at telomeres, they can become fragile (green arrows), sending cells into senescence. The inset shows an enlarged chromosome with fragile telomeres, indicated by multiple green spots at chromosome tips.

Credit

Barnes et al., Nature Structural & Molecular Biology, 10.1038/s41594-022-00790-y (2022)

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