Release mechanism of SASP factors from hepatic stellate cells and their tumorigenic orchestration (IMAGE)

Osaka Metropolitan University

Release mechanism of SASP factors from hepatic stellate cells and their tumorigenic orchestration

Caption

High-fat diets weaken gut barrier function, resulting in the migration and accumulation of lipoteichoic acid in the liver. The accumulated lipoteichoic acid stimulates the cleavage of gasdermin D protein, forming cell membrane pores where the SASP factors IL-1β and IL-33 are released from hepatic stellate cells. IL-33 activates regulatory T cells that suppress immune response, accelerating cancer development.

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Osaka Metropolitan University

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