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The Korea Advanced Institute of Science and Technology (KAIST)

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(a) Random copolymerization of hydrophilic and hydrophobic monomers. Three binary sequences that can be generated by the random copolymerization are given as examples for the copolymer consisting of 23 repeating units. (b) A random sequence can be drastically heterogeneous and contain hydrophilic- and hydrophobic-rich local sequences. When the chains associate in water via hydrophobic interaction, local sequence mismatches can take place for long chains leading to folding because of the curvature instability.

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KAIST

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